Fluorescein was conjugated with 1-methyl-o-carborane and the resulting bioconjugate was biologically evaluated through microscopic and flow cytometric studies in pancreatic cancer and squamous cell carcinoma cell lines. The uniform distribution of this bioconjugate, as well as its moderate cytotoxicity and higher boron content relative to present boronated delivery agents sodium borocaptate (BSH) and boronophenylalanine (BPA), provide justification for its further evaluation as a potential delivery agent for BNCT.
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Patel H, Takagaki M, Bode BP. Snajdr I, Devangi P. et al. Carborane-Appended Saccharides: Prime Candidates for Boron Neutron Capture Therapy (BNCT). Biochemical and Biophysical Journal of Neutron Capture Therapy & Cancer Treatments. 2013; 1: 15-21. Ref.: https://goo.gl/Bjm4n6
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Hattori Y, Kusaka S, Mukumoto M, Uehara K, Asano T, et al. Biological Evaluation of Dodecaborate-Containing L-Amino Acids for Boron Neutron Capturer Therapy. J Med Chem. 2012; 55: 6980–6984. Ref.: https://goo.gl/o6bZC9
Agarwal HK, Khalil A, Ishita K, Yang W, Nakkula RJ, et al. Synthesis and evaluation of thymidine-kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer. Eur J Med Chem. 2015; 100: 197-209. Ref.: https://goo.gl/iGQKtN
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Francaviglia N, Iacopino DG, Costantino G, Villa A, Impallaria P, et al. Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature. Surg Neurol Int. 2017; 8: 145. Ref.: https://goo.gl/ToXJhB
Acerbi F, Cavallo C, Broggi M, Cordella R, Anghileri E, et al. Fluorescein-guided surgery for malignant gliomas: a review. Neurosurg Rev. 2014; 37: 547-57. Ref.: https://goo.gl/5QZGXw
Xuan S, Zhao N, Zhou Z, Fronczek FR, Vicente MG. Synthesis and in Vitro Studies of a Series of CarboraneContaining Boron Dipyrromethenes (BODIPYs). J Med Chem. 2016; 59: 2109−2117. Ref.: https://goo.gl/ccX6Y8
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Lucas A Kuzmanic, Lauren E Zuidema, Jason A Misurelli, Kazuko Uno, Sherine F Elsawa*, Masao Takagaki* and Narayan S Hosmane*Lucas A Kuzmanic,Lauren E Zuidema,Jason A Misurelli,Kazuko Uno,Sherine F Elsawa*,Masao Takagaki*,Narayan S Hosmane*. Synthesis and Biological Evaluation of Fluorescein-Tagged 1-Methyl-o-carborane for Boron Neutron Capture Therapy. . 2018 doi: 10.29328/journal.aac.1001016; 2: 075-081
EB Simão-Silva, NFG Serrano, MPC de Medeiros, AJ Boareto-Mendes, JF Galdino and FM Araujo-Moreira*EB Simão-Silva, NFG Serrano, MPC de Medeiros, AJ Boareto-Mendes, JF Galdino, FM Araujo-Moreira*. Nuclear science and magnetic carbon: a promising way from a chemical method to detect and fight cancer and tumors/neoplasms. . 2023 doi: 10.29328/journal.aac.1001042; 7: 047-050
Ekpenyong CE*, Patrick ES and Akpan KSEkpenyong CE*,Patrick ES,Akpan KS. Changes in Serum Markers of Atherogenesis and Hematological Profile after the consumption of Quail eggs. Arch Food Nutr Sci. 2017: doi: 10.29328/journal.afns.1001001; 1: 001-011
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H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024 doi: 10.29328/journal.acr.1001099; 8: 075-077
Denis Tonini, Kai Wu, Renata Saha and Jian-Ping Wang*Denis Tonini,Kai Wu,Renata Saha,Jian-Ping Wang*. Feasibility study of magnetic sensing for detecting single-neuron action potentials. Ann Biomed Sci Eng. 2022 doi: 10.29328/journal.abse.1001018; 6: 019-029
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