Synthesis of some new Schiff bases of Pharmaceutical Interest

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Submitted: August 17, 2017
Published: Sep 26, 2017
DOI: 10.29328/journal.aac.1001006
Keywords:
Schiff base, Diphenylamine derivative, Antibacterial activity, Amines

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Ajay Kumar
Faculty of Pharmacy, IFTM University, Moradabad-244102(U.P), India
Shweta Verma
Faculty of Pharmacy, IFTM University, Moradabad-244102(U.P), India
Arun K Mishra
Faculty of Pharmacy, IFTM University, Moradabad-244102(U.P), India
Sushil Kumar
Faculty of Pharmacy, IFTM University, Moradabad-244102(U.P), India

Abstract

A series of Schiff bases of diphenylamine derivatives have been synthesized and evaluated in vitro for their antibacterial activity against pathogenic both Gram-positive bacteria B. subtilis and Gram-negative bacteria E. coli using ciprofloxacin as standard drug at conc. of 50 µg/ml and 100 µg/ml. The structures of these compounds were established on the basis of IR and 1H-NMR spectral analysis. The compound (3d) displayed potent antibacterial activity against Bacillus subtilis (17 and 15mm) and Escherichia coli (19 and 17mm) by disc diffusion method.

Article Details

Kumar, A., Verma, S., Mishra, A. K., & Kumar, S. (2017). Synthesis of some new Schiff bases of Pharmaceutical Interest. Annals of Advances in Chemistry, 1(1), 053–056. https://doi.org/10.29328/journal.aac.1001006
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Copyright (c) 2017 Kumar A, et al.

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