Computational Simulation of Phase-Molecular Separation-DNA/RNA-Related Function Based on Gene Ontology using Combination of Computational Fluid Dynamics, Machine Learning and Membrane Systems

Alireza Heidari

Abstract

Review Article

Computational Simulation of Phase-Molecular Separation-DNA/RNA-Related Function Based on Gene Ontology using Combination of Computational Fluid Dynamics, Machine Learning and Membrane Systems

Alireza Heidari*

Published: 21 May, 2025 | Volume 9 - Issue 1 | Pages: 009-018

Our evaluation and its outcomes/outcomes/hints spotlight that gaining a (having to do with measuring matters with numbers) knowledge of the proteome company in living cells, and its outcomes/consequences/tips for the (introduction and production/ organization of objects) of condensates and MLOs, is a critical assignment that the section separation field wishes to face/address. Our findings that dosage-sensitive (tiny chemical meeting commands interior of living things), insufficient (tiny chemical meeting commands internal of living things) and homologs especially, are overrepresented amongst human LLPS drivers, spotlight furthermore the needed component of preserving the mobile (oversupply/huge quantity) of the (bearing on everyone or issue) DNA/RNA merchandise at a great degree well suited with tightly managed LLPS conduct, to keep away from extreme (diseases/the have a look at of diseases) that unexpected errors in any direction may also cause. In-depth close interest of the records on DNA/RNA concentrations used in the LLPS experiments assisting our excessive self-belief dataset of human driver DNA/RNA s laid the uncertainties related with defining the frame-shape-related meaningful ranges of this essential restriction/guiding principle that leads and controls condensate (introduction and production/ organization of items), and recommended how those uncertainties can be lessened (something awful) and (ultimately) shortened.
Graphical abstract: Computational Simulation of Phase-Molecular Separation-DNA/RNA-Related Function Based on Gene Ontology Using Combination of Computational Fluid Dynamics, Machine Learning and Membrane Systems.

Read Full Article HTML DOI: 10.29328/journal.aac.1001055 Cite this Article Read Full Article PDF

Keywords:
Computational simulation; Phase-molecular separation; DNA/RNA; Gene ontology; Fluid dynamics; Machine learning; Membrane systems

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Heidari A. Sydnone, Münchnone, Montréalone, Mogone, Montelukast, Quebecol and Palau’amine–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules. Sur Cas Stud Op Acc J. 2018;1(3). Available from: http://dx.doi.org/10.32474/SCSOAJ.2018.01.000113
Heidari A. Fornacite, orotic acid, rhamnetin, sodium ethyl xanthate (SEX) and spermine (spermidine or polyamine) nanomolecules incorporation into the nanopolymeric matrix (NPM). Int J Biochem Biomol. 2018;4(1):1–19. Available from: https://doi.org/10.37628/ijbb.v4i1.289
Heidari A, Gobato R. Putrescine, cadaverine, spermine and spermidine–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules. Parana J Sci Educ. 2018;4(5):1–14. Available from: https://www.openaccessjournals.com/articles/putrescine-cadaverine-spermine-and-spermidine--enhanced-precatalyst-preparation-stabilization-and-initiation-eppsi-nano-.pdf
Heidari A. Cadaverine (1,5–pentanediamine or pentamethylenediamine), diethyl azodicarboxylate (DEAD or DEADCAT) and putrescine (tetramethylenediamine) nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. HIV Sex Health Open J. 2018;1(1):4–11. Available from: https://www.sciepub.com/reference/369530
Heidari A. Improving the performance of nano–endofullerenes in polyaniline nanostructure–based biosensors by covering californium colloidal nanoparticles with multi–walled carbon nanotubes. J Adv Nanomater. 2018;3(1):1–28. Available from: http://dx.doi.org/10.22606/jan.2018.31001
Gobato R, Heidari A. Molecular mechanics and quantum chemical study on sites of action of sanguinarine using vibrational spectroscopy based on molecular mechanics and quantum chemical calculations. Malays J Chem. 2018;20(1):1–23. Available from: https://www.researchgate.net/publication/327395016
Heidari A. Vibrational biospectroscopic studies on anti–cancer nanopharmaceuticals (Part I). Malays J Chem. 2018;20(1):33–73. Available from: https://www.sciepub.com/reference/381168
Heidari A. Vibrational biospectroscopic studies on anti–cancer nanopharmaceuticals (Part II). Malays J Chem. 2018;20(1):74–117. Available from: https://www.sciepub.com/reference/369534
Heidari A. Uranocene (U(C₈H₈)₂) and bis(cyclooctatetraene)iron (Fe(C₈H₈)₂ or Fe(COT)₂)–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules. Chem Rep. 2018;1(2):1–16. Available from: https://www.semanticscholar.org/paper/Uranocene-(U(C8H8)2)-and-Bis(Cyclooctatetraene)Iron-Heidari/f256e15bc3478e7fe814ccb25cc3a45239a61d2e
Heidari A. Biomedical systematic and emerging technological study on human malignant and benign cancer cells and tissues biospectroscopic analysis under synchrotron radiation. Glob Imaging Insights. 2018;3(3):1–7. Available from: https://www.oatext.com/pdf/GII-3-158.pdf
Heidari A. Deep–level transient spectroscopy and X–ray photoelectron spectroscopy (XPS) comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation. Res Dev Mater Sci. 2018;7(2). Available from: http://dx.doi.org/10.31031/RDMS.2018.07.000659
Heidari A. C70–carboxyfullerenes nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Glob Imaging Insights. 2018;3(3):1–7. Available from: https://oatext.com/c70-carboxyfullerenes-nano-molecules-incorporation-into-the-nano-polymeric-matrix.php
Heidari A. The effect of temperature on cadmium oxide (CdO) nanoparticles produced by synchrotron radiation in the human cancer cells, tissues and tumors. Int J Adv Chem. 2018;6(2):140–156. Available from: https://www.sciencepubco.com/index.php/IJAC/article/view/12521
Heidari A. A clinical and molecular pathology investigation of correlation spectroscopy (COSY), exclusive correlation spectroscopy (ECOSY), total correlation spectroscopy (TOCSY), heteronuclear single–quantum correlation spectroscopy (HSQC) and heteronuclear multiple–bond correlation spectroscopy (HMBC) comparative study on malignant and benign human cancer cells, tissues and tumors under synchrotron and synchrocyclotron radiations using cyclotron versus synchrotron, synchrocyclotron and the Large Hadron Collider (LHC) for delivery of proton and helium ion (charged particle) beams for oncology radiotherapy. Eur J Adv Eng Technol. 2018;5(7):414–426. Available from: https://ejaet.com/PDF/5-7/EJAET-5-7-414-426.pdf
Heidari A. Nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. J Oncol Res. 2018;1(1):1–20.
Heidari A. Use of molecular enzymes in the treatment of chronic disorders. Canc Oncol Open Access J. 2018;1(1):12–15. Available from: https://www.sciepub.com/reference/367953
Heidari A. Vibrational biospectroscopic study and chemical structure analysis of unsaturated polyamides nanoparticles as anti–cancer polymeric nanomedicines using synchrotron radiation. Int J Adv Chem. 2018;6(2):167–189. Available from: https://www.sciencepubco.com/index.php/IJAC/article/view/12528
Heidari A. Adamantane, irene, naftazone and pyridine–enhanced precatalyst preparation stabilization and initiation (PEPPSI) nano molecules. Madridge J Nov Drug Res. 2018;2(1):61–67. Available from: http://dx.doi.org/10.18689/mjndr-1000109
Heidari A. Heteronuclear single–quantum correlation spectroscopy (HSQC) and heteronuclear multiple–bond correlation spectroscopy (HMBC) comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation. Madridge J Nov Drug Res. 2018;2(1):68–74. Available from: http://dx.doi.org/10.18689/mjndr-1000110
Heidari A, Gobato R. A novel approach to reduce toxicities and to improve bioavailabilities of DNA/RNA of human cancer cells–containing cocaine (coke), lysergide (lysergic acid diethyl amide or LSD), Δ⁹–tetrahydrocannabinol (THC), theobromine, caffeine, aspartame (APM) and zidovudine (ZDV) as anti–cancer nano drugs by coassembly of dual anti–cancer nano drugs to inhibit DNA/RNA of human cancer cells drug resistance. Parana J Sci Educ. 2018;4(6):1–17. Available from: https://www.researchgate.net/publication/326925595
Heidari A, Gobato R. Ultraviolet photoelectron spectroscopy (UPS) and ultraviolet–visible (UV–Vis) spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation. Parana J Sci Educ. 2018;4(6):18–33. Available from: http://dx.doi.org/10.13140/RG.2.2.18899.68647
Gobato R, Heidari A, Mitra A. The creation of C13H20BeLi2SeSi. The proposal of a bio–inorganic molecule, using ab initio methods for the genesis of a nano membrane. Arc Org Inorg Chem Sci. 2018;3(4). Available from: https://www.researchgate.net/publication/326957287
Gobato R, Heidari A. Using the quantum chemistry for genesis of a nano biomembrane with a combination of the elements Be, Li, Se, Si, C and H. J Nanomed Res. 2018;7(4):241–252. Available from: http://dx.doi.org/10.15406/jnmr.2018.07.00194
Heidari A. Bastadins and bastaranes–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules. Glob Imaging Insights. 2018;3(4):1–7. Available from: https://oatext.com/bastadins-and-bastaranes%E2%80%93enhanced-precatalyst-preparation-stabilization-and-initiation-eppsi-nano-molecules.php
Heidari A. Fucitol, pterodactyladiene, DEAD or DEADCAT (diethyl azodicarboxylate), skatole, the NanoPutians, thebacon, pikachurin, tie fighter, spermidine and mirasorvone nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Glob Imaging Insights. 2018;3(4):1–8. Available from: https://www.oatext.com/fucitol-pterodactyladiene-dead-or-deadcat-diethyl-azodicarboxylate-skatole-the-nanoputians-thebacon-pikachurin-tie-fighter.php
Dadvar E, Heidari A. A review on separation techniques of graphene oxide (GO)/base on hybrid polymer membranes for eradication of dyes and oil compounds: recent progress in graphene oxide (GO)/base on polymer membranes–related nanotechnologies. Clin Med Rev Case Rep. 2018;5:228. Available from: https://www.clinmedjournals.org/articles/cmrcr/clinical-medical-reviews-and-case-reports-cmrcr-5-228.php?jid=cmrcr
Heidari A, Gobato R. First–time simulation of deoxyuridine monophosphate (dUMP) and vomitoxin (deoxynivalenol (DON))–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Parana J Sci Educ. 2018;4(6):46–67. Available from: https://vixra.org/pdf/1811.0456v1.pdf
Heidari A. Buckminsterfullerene (fullerene), bullvalene, dickite and Josiphos ligands nano molecules incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human hematology and thromboembolic diseases prevention, diagnosis and treatment under synchrotron and synchrocyclotron radiations. Glob Imaging Insights. 2018;3(4):1–7. Available from: https://www.oatext.com/buckminsterfullerene-fullerene-bullvalene-dickite-and-josiphos-ligands-nano-molecules-incorporation-into-the-nano-polymeric-matrix.php
Heidari A. Fluctuation X–ray scattering (FXS) and wide–angle X–ray scattering (WAXS) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation. Glob Imaging Insights. 2018;3(4):1–7. Available from: https://oatext.com/fluctuation-x%E2%80%93ray-scattering-fxs-and-wide%E2%80%93angle-x%E2%80%93ray-scattering-waxs-comparative-study-on-malignant-and-benign-human-cancer-cells-and-tissues-under-synchrotron-radiation.php
Heidari A. A novel approach to correlation spectroscopy (COSY), exclusive correlation spectroscopy (ECOSY), total correlation spectroscopy (TOCSY), incredible natural–abundance double–quantum transfer experiment (INADEQUATE), heteronuclear single–quantum correlation spectroscopy (HSQC), heteronuclear multiple–bond correlation spectroscopy (HMBC), nuclear Overhauser effect spectroscopy (NOESY) and rotating frame nuclear Overhauser effect spectroscopy (ROESY) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation. Glob Imaging Insights. 2018;3(5):1–9. Available from: https://www.oatext.com/pdf/GII-3-168.pdf
Heidari A. Terphenyl–based reversible receptor with rhodamine, rhodamine–based molecular probe, rhodamine–based using the spirolactam ring opening, rhodamine B with ferrocene substituent, calix[4]arene–based receptor, thioether + aniline–derived ligand framework linked to a fluorescein platform, mercuryfluor–1 (fluorescent probe), N,N’–dibenzyl–1,4,10,13–tetraraoxa–7,16–diazacyclooctadecane and terphenyl–based reversible receptor with pyrene and quinoline as the fluorophores–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules. Glob Imaging Insights. 2018;3(5):1–9. Available from: https://www.oatext.com/pdf/GII-3-169.pdf
Heidari A. Small–angle X–ray scattering (SAXS), ultra–small angle X–ray scattering (USAXS), fluctuation X–ray scattering (FXS), wide–angle X–ray scattering (WAXS), grazing–incidence small–angle X–ray scattering (GISAXS), grazing–incidence wide–angle X–ray scattering (GIWAXS), small–angle neutron scattering (SANS), grazing–incidence small–angle neutron scattering (GISANS), X–ray diffraction (XRD), powder X–ray diffraction (PXRD), wide–angle X–ray diffraction (WAXD), grazing–incidence X–ray diffraction (GIXD) and energy–dispersive X–ray diffraction (EDXRD) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation. Glob Imaging Insights. 2018;3(5):1–10. Available from: https://www.oatext.com/small-angle-x-ray-scattering-saxs-ultra-small-angle-x-ray-scattering-usaxs-fluctuation-x-ray-scattering-fxs-wide-angle-x-ray-scattering-waxs-grazing-incidence-small.php
Heidari A. Nuclear resonant inelastic X–ray scattering spectroscopy (NRIXSS) and nuclear resonance vibrational spectroscopy (NRVS) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation. Glob Imaging Insights. 2018;3(5):1–7. Available from: https://www.oatext.com/nuclear-resonant-inelastic-x-ray-scattering-spectroscopy-nrixss-and-nuclear-resonance-vibrational-spectroscopy-nrvs-comparative-study-on-malignant-and-benign-human-cancer-cells.php
Heidari A. Small–angle X–ray scattering (SAXS) and ultra–small angle X–ray scattering (USAXS) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation. Glob Imaging Insights. 2018;3(5):1–7. Available from: https://www.oatext.com/small-angle-x-ray-scattering-saxs-and-ultra-small-angle-x-ray-scattering-usaxs-comparative-study-on-malignant-and-benign-human-cancer.php
Heidari A. Curious chloride (CmCl3) and titanic chloride (TiCl4)–enhanced precatalyst preparation stabilization and initiation (EPPSI) nano molecules for cancer treatment and cellular therapeutics. J Cancer Res Ther Interv. 2018;1(1):1–10. Available from: https://www.auctoresonline.org/article/curious-chloride-28cmcl329-and-titanic-chloride-28ticl429E28093enhanced-precatalyst-preparation-stabilization-and-initiation-28eppsi29-nano-molecules-for-cancer-treatment-and-cellular-therapeutics
Gobato R, Gobato MRR, Heidari A, Mitra A. Spectroscopy and dipole moment of the molecule C13H20BeLi2SeSi via quantum chemistry using ab initio, Hartree–Fock method in the base set CC–pVTZ and 6–311G**(3df, 3pd). Arc Org Inorg Chem Sci. 2018;3(5):402–409. Available from: http://dx.doi.org/10.32474/AOICS.2018.03.000171
Heidari A. C60 and C70–encapsulating carbon nanotubes incorporation into the nano polymeric matrix (NPM) by immersion of the nano polymeric modified electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Integr Mol Med. 2018;5(3):1–8. Available from: https://www.oatext.com/c60-and-c70-encapsulating-carbon-nanotubes-incorporation-into-the-nano-polymeric-matrix-npm-by-immersion-of-the-nano-polymeric-modified.php
Heidari A. Two–dimensional (2D) 1H or proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation with the passage of time. Glob Imaging Insights. 2018;3(6):1–8. Available from: https://www.oatext.com/two-dimensional-2d-1h-or-proton-nmr-13c-nmr-15n-nmr-and-31p-nmr-spectroscopy-comparative-study-on-malignant-and-benign-human-cancer-cells-and-tissues-under-synchrotron-radiation-with-the-passage-of-time.php
Heidari A. FT–Raman spectroscopy, coherent anti–Stokes Raman spectroscopy (CARS) and Raman optical activity spectroscopy (ROAS) comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation. Glob Imaging Insights. 2018;3(6):1–8. Available from: https://www.oatext.com/ft-raman-spectroscopy-coherent-anti-stokes-raman-spectroscopy-cars-and-raman-optical-activity-spectroscopy-roas-comparative-study-on-malignant-and-benign-human-cancer-cells-and-tissues.php
Heidari A. A modern and comprehensive investigation of inelastic electron tunneling spectroscopy (IETS) and scanning tunneling spectroscopy on malignant and benign human cancer cells, tissues and tumors through optimizing synchrotron microbeam radiotherapy for human cancer treatments and diagnostics: an experimental biospectroscopic comparative study. Glob Imaging Insights. 2018;3(6):1–8. Available from: https://www.oatext.com/pdf/GII-3-175.pdf

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Your journal has accomplished its intended mission of providing very effective and efficient goals in dealing with submissions, conducting the reviewing process and in publishing accepted manuscripts in a timely manner. Keep up the great work and services that you provide.

University of Jacqmar, Inc., USA

John St. Cyr

I am to express my view that Heighten Science Publications are reliable quick even after peer review process. I hope and wish the publications will go a long way in disseminating science to many interested in scientific research.

College of Fisheries, CAU(I), Tripura, India

Ajit Kumar Roy

The Journal Clinical Nephrology provides a good opportunity for readers to stay updated in the field of clinical nephrology. Additionally - it provides a good opportunity for authors to publish their work. 1. Publication of the accepted manuscripts is sufficiently rapid. 2. The trust factor between the journal and me, as an author, is very important and well preserved. 3. Peer review process very rapid and effective.

Assaf Harofeh Medical Center, Israel

Leonid Feldman

In 2017, I submitted a manuscript to the journal Archives of Biotechnology and Biomedicine belonging to Heighten Science Publications Corporation. Within one week I already received the response from the editor. All processing steps were really fast so in terms of a speedy publication I can particularly recommend the journal Archives of Biotechnology and Biomedicine. The responsible contact person of the journal was always available, which gives a trustworthy impression to the author. Also the peer review process was clear and constructive. So from my experience with Heighten Science Publications Corporation I can recommend publishing there.

University of Tubingen, Germany

Yvonne Mast

We thank to the heighten science family, who speed up the publication of our article and provide every support.

Mehmet Besir

The services of the journal were excellent. The most important thing for an author is the speed of the peer review which was really fast here. They returned in a few days and immediately replied all of my questions. I want to refer this platform to all scholars. Many thanks.

Eastern Mediterranean University, Cyprus

Zehra Guchan TOPCU

Thank you for your attitude and support. I am sincerely grateful to you and the entire staff of the magazine for the high professionalism and fast quality work. Thank you very much!

USA

Igor Klepikov

Thank you and your company for effective support of authors which are very much dependable on the funds gambling for science in the different countries of our huge and unpredictable world. We are doing our work and should rely on a teams like Galley Proof-HSPC. Great success to all of you for the 2019th! Be well all the year long.

Russia

Victor V Apollonov

The editorial process was quickly done. The galley proof was sent within a week after being accepted for publication. The editorial team was very helpful and responded promptly.

India

Rohit Kulshrestha

University of Port Harcourt Teaching Hospital, Nigeria

Dr. Elizabeth A Awoyesuku

"It was a pleasure to work with the editorial team of the journal on the submission of the manuscript. The team was professional, fast, and to the point".

NC A&T State University, USA

Moran Sciamama-Saghiv

Submission of paper was smooth, the review process was fast. I had excellent communication and on time response from the editor.

Ekiti State University Teaching Hospital, Nigeria

Ayokunle Dada

I am delighted and satisfied with. Heighten Science Publications as my manuscript was thoroughly assessed and published on time without delay. Keep up the good work.

Ido-Ekiti/Afe Babalola University, Nigeria

Dr. Shuaib Kayode Aremu

Ekiti State University, Nigeria

Adebukola Ajite

I wanna to thank clinical journal of nursing care and practice for its effort to review and publish my manuscript. This is reputable journal. Thank you!

Wollo University, Ethiopia

Atsedemariam Andualem

We appreciate your approach to scholars and will encourage you to collaborate with your organization, which includes interesting and different medical journals. With the best wishes of success, creativity and joy in life, prosperity in the medical field.

Ivano- Frankivsk National Medical University, Ukraine

Nataliya Kitsera

Thank you very much for your support and encouragement. I am truly impressed by your tolerance and support. Thank you very much

Diaverum: PADC, Jeddah, Saudi Arabia

Nasrulla Abutaleb

You are such a nice person. Your journal co-operation is very appreciable and motivational.

Department of Biotechnology, Uttaranchal college of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India

Archna Dhasmana

“Mobile apps and wearable technology are becoming ubiquitous in our environment. Their integration with healthcare delivery is just beginning to take shape. The early results are promising and the possibilities great."

BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA

Helen Figge

Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA